KDM4D

KDM4D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DXT, 3DXU, 4D6Q, 4D6R, 4D6S, 4HON, 4HOO, 5FP9, 5F5A, 5FP8, 5FPA, 5FPB, 5FP4, 5F5C
Identifiers
Aliases	KDM4D, JMJD2D, lysine demethylase 4D
External IDs	OMIM: 609766; MGI: 3606484; HomoloGene: 69244; GeneCards: KDM4D; OMA:KDM4D - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	94,999,519 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	14,411,778 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; left testis; ; right testis; ; testicle; ; gonad; ; sperm; ; secondary oocyte; ; ventricular zone; ; islet of Langerhans; ; stromal cell of endometrium;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; spermatid; ; lumbar spinal ganglion; ; embryo; ; lumbar subsegment of spinal cord; ; facial motor nucleus; ; primary visual cortex; ; superior frontal gyrus; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; dioxygenase activity; metal ion binding; histone demethylase activity; histone H3-methyl-lysine-9 demethylase activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding; damaged DNA binding; chromatin DNA binding; methylated histone binding;
Cellular component	blood microparticle; nucleus; nucleoplasm; site of double-strand break; pericentric heterochromatin; histone methyltransferase complex;
Biological process	regulation of protein phosphorylation; cellular response to ionizing radiation; regulation of transcription, DNA-templated; positive regulation of chromatin binding; double-strand break repair via homologous recombination; transcription, DNA-templated; positive regulation of double-strand break repair via nonhomologous end joining; histone H3-K9 demethylation; negative regulation of transcription by RNA polymerase II; chromatin organization; cellular response to DNA damage stimulus; negative regulation of histone H3-K9 trimethylation; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	55693
	244694
	ENSG00000186280
	ENSMUSG00000053914
	Q6B0I6
	Q3U2K5
	NM_018039
	NM_173433
	NP_060509
	NP_775609
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene. KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

In 2017, messenger RNA from this gene was used in the somatic cell nuclear transfer experiment that produced the first two cloned primates from post-embryonic donor material. A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.