KDM5C

KDM5C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JRZ, 5FWJ
Identifiers
Aliases	KDM5C, DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169, lysine demethylase 5C
External IDs	OMIM: 314690; MGI: 99781; HomoloGene: 79498; GeneCards: KDM5C; OMA:KDM5C - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	53,225,422 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	151,057,531 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; stromal cell of endometrium; ; right uterine tube; ; body of uterus; ; left ovary; ; granulocyte; ; right ovary; ; ectocervix; ; skin of leg; ; skin of abdomen;
	Top expressed in
	epithelium of lens; ; yolk sac; ; pineal gland; ; neural layer of retina; ; fossa; ; condyle; ; substantia nigra; ; trigeminal ganglion; ; retinal pigment epithelium; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; oxidoreductase activity; dioxygenase activity; metal ion binding; histone demethylase activity; zinc ion binding; histone H3-methyl-lysine-4 demethylase activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding; histone H3-tri/di/monomethyl-lysine-4 demethylase activity; methylated histone binding;
Cellular component	nucleus; nucleoplasm; cytosol; histone methyltransferase complex;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; rhythmic process; response to toxic substance; histone H3-K4 demethylation; chromatin organization; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; histone H3-K4 demethylation, trimethyl-H3-K4-specific; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	8242
	20591
	ENSG00000126012
	ENSMUSG00000025332
	P41229
	P41230
NM_001146702; NM_001282622; NM_004187; NM_001353978; NM_001353979;
	NM_001353981; NM_001353982; NM_001353984
	NM_013668
NP_001140174; NP_001269551; NP_004178; NP_001340907; NP_001340908;
	NP_001340910; NP_001340911; NP_001340913
NP_038696; NP_001390000; NP_001390001; NP_001390002; NP_001390003;
	NP_001390004; NP_001390005
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 5C is an enzyme that in humans is encoded by the KDM5C gene. KDM5C belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.