KDM5D

KDM5D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E6R, 2YQE
Identifiers
Aliases	KDM5D, HY, HYA, JARID1D, SMCY, lysine demethylase 5D
External IDs	OMIM: 426000; MGI: 99780; HomoloGene: 55838; GeneCards: KDM5D; OMA:KDM5D - orthologs
Gene location (Human)
Chr.	Y chromosome (human)
End	19,744,939 bp
Gene location (Mouse)
Chr.	Y chromosome (mouse)
End	956,786 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; rectum; ; right lung; ; prostate; ; skin of thigh; ; mucosa of transverse colon; ; urethra; ; trabecular bone; ; gonad; ; Brodmann area 9;
	Top expressed in
	tail of embryo; ; left lung lobe; ; internal carotid artery; ; external carotid artery; ; female urethra; ; granulocyte; ; male urethra; ; vas deferens; ; triceps brachii muscle; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone H3-methyl-lysine-4 demethylase activity; DNA binding; oxidoreductase activity; dioxygenase activity; metal ion binding; histone demethylase activity; androgen receptor binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding; histone H3-tri/di/monomethyl-lysine-4 demethylase activity; methylated histone binding;
Cellular component	nucleus; nucleoplasm; fibrillar center; cellular component; histone methyltransferase complex;
Biological process	histone H3-K4 demethylation; T cell antigen processing and presentation; transcription, DNA-templated; regulation of transcription, DNA-templated; regulation of androgen receptor signaling pathway; chromatin organization; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; histone H3-K4 demethylation, trimethyl-H3-K4-specific; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	8284
	20592
	ENSG00000012817
	ENSMUSG00000056673
	Q9BY66
	Q62240
	NM_001146705; NM_001146706; NM_004653
	NM_011419
	NP_001140177; NP_001140178; NP_004644
	NP_035549
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 5D is an enzyme that in humans is encoded by the KDM5D gene. KDM5D belongs to the alpha-ketoglutarate-dependent hydroxylases superfamily.

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.