KDM8

KDM8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UYJ, 4AAP, 4GAZ, 4GJY, 4GJZ, 4QU1
Identifiers
Aliases	KDM8, JMJD5, lysine demethylase 8
External IDs	OMIM: 611917; MGI: 1924285; HomoloGene: 49791; GeneCards: KDM8; OMA:KDM8 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	27,221,768 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	125,061,441 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; testicle; ; gonad; ; granulocyte; ; apex of heart; ; epithelium of colon; ; body of pancreas; ; prefrontal cortex; ; mucosa of transverse colon;
	Top expressed in
	retinal pigment epithelium; ; primitive streak; ; cumulus cell; ; neural layer of retina; ; embryo; ; morula; ; secondary oocyte; ; ventricular zone; ; triceps brachii muscle; ; Rostral migratory stream;
	More reference expression data
	n/a
Gene ontology
Molecular function	dioxygenase activity; chromatin binding; oxidoreductase activity; metal ion binding; histone H3-methyl-lysine-36 demethylase activity; histone demethylase activity; protein binding; peptidase activity; hydrolase activity; aminopeptidase activity; endopeptidase activity; 2-oxoglutarate-dependent dioxygenase activity; methylated histone binding;
Cellular component	nucleus; nucleoplasm; cytosol; chromosome;
Biological process	regulation of transcription, DNA-templated; cell cycle; G2/M transition of mitotic cell cycle; positive regulation of transcription, DNA-templated; histone H3-K36 demethylation; transcription, DNA-templated; proteolysis; chromatin organization; protein destabilization; circadian regulation of gene expression; negative regulation of transcription, DNA-templated; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	79831
	77035
	ENSG00000155666
	ENSMUSG00000030752
	Q8N371
	Q9CXT6
	NM_001145348; NM_024773
	NM_029842
	NP_001138820; NP_079049
	NP_084118
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine demethylase 8 is a protein that in humans is encoded by the KDM8 gene.