3-dehydrosphinganine reductase

KDSR
Identifiers
Aliases	KDSR, Kdsr, 6330410P18Rik, 9430079B08Rik, Fvt1, DHSR, SDR35C1, 3-ketodihydrosphingosine reductase, 3-dehydrosphinganine reductase, EKVP4
External IDs	OMIM: 136440; MGI: 1918000; HomoloGene: 1539; GeneCards: KDSR; OMA:KDSR - orthologs
EC number	1.1.1.102
Gene location (Human)
Chr.	Chromosome 18 (human)
End	63,367,228 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	106,687,457 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; buccal mucosa cell; ; C1 segment; ; nipple; ; skin of leg; ; palpebral conjunctiva; ; epithelium of colon; ; skin of abdomen; ; parotid gland; ; internal globus pallidus;
	Top expressed in
	decidua; ; gastrula; ; otolith organ; ; utricle; ; cumulus cell; ; retinal pigment epithelium; ; pineal gland; ; iris; ; otic vesicle; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; 3-dehydrosphinganine reductase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; extracellular space;
Biological process	3-keto-sphinganine metabolic process; sphingolipid biosynthetic process; lipid metabolism; sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2531
	70750
	ENSG00000119537
	ENSMUSG00000009905
	Q06136
	Q6GV12
	NM_002035
	NM_027534; NM_001316750
	NP_002026
	NP_001303679; NP_081810
	Wikidata
View/Edit Human	View/Edit Mouse

Search
PMC	articles
PubMed	articles
NCBI	proteins

3-dehydrosphinganine reductase
3-dehydrosphinganine reductase
Identifiers
EC no.	1.1.1.102
CAS no.	37250-36-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

3-dehydrosphinganine reductase (EC 1.1.1.102) also known as 3-ketodihydrosphingosine reductase (KDSR) or follicular variant translocation protein 1 (FVT1) is an enzyme that in humans is encoded by the KDSR gene.