KIDINS220

KIDINS220
Identifiers
Aliases	KIDINS220, ARMS, kinase D-interacting substrate 220kDa
External IDs	OMIM: 615759; MGI: 1924730; HomoloGene: 14254; GeneCards: KIDINS220; OMA:KIDINS220 - orthologs
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	25,113,151 bp
RNA expression pattern
	n/a
	Top expressed in
	vestibular membrane of cochlear duct; ; trigeminal ganglion; ; neural layer of retina; ; superior cervical ganglion; ; otolith organ; ; utricle; ; Rostral migratory stream; ; molar; ; substantia nigra; ; facial motor nucleus;
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase regulator activity; PDZ domain binding;
Cellular component	integral component of membrane; cytosol; late endosome; endosome; membrane; protein-containing complex;
Biological process	regulation of protein kinase activity; cellular response to nerve growth factor stimulus; in utero embryonic development; dendrite morphogenesis; nervous system development; positive regulation of neuron projection development; nerve growth factor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57498
	77480
	ENSG00000134313
	ENSMUSG00000036333
	Q9ULH0
	E9Q9B7
	NM_020738
	NM_001081378
NP_065789; NP_001335658; NP_001335660; NP_001335661; NP_001335663;
	NP_001335664; NP_001335665; NP_001335667; NP_001335668; NP_001335669; NP_001335670; NP_001335671; NP_001335672; NP_001335674
	NP_001074847
	Wikidata
View/Edit Human	View/Edit Mouse

Kinase D-interacting substrate of 220 kDa or ARMS (ankyrin repeat-rich membrane spanning) is a scaffold protein that in humans is encoded by the KIDINS220 gene.

It is a downstream target of neuronal signaling events initiated by neutrophins and ephrins. Additionally, it was shown to have important roles in the immune system by interacting with the B-cell and T-cell receptor.