Kinesin-like protein KIF11

KIF11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1II6, 1Q0B, 1X88, 1YRS, 2FKY, 2FL2, 2FL6, 2FME, 2G1Q, 2GM1, 2IEH, 2PG2, 2Q2Y, 2Q2Z, 2UYI, 2UYM, 2WOG, 2X2R, 2X7C, 2X7D, 2X7E, 2XAE, 3CJO, 3HQD, 3K3B, 3K5E, 3KEN, 3L9H, 3WPN, 3ZCW, 4A1Z, 4A28, 4A50, 4A51, 4A5Y, 4AP0, 4AQV, 4AQW, 4AS7, 4B7B, 4BBG, 4BXN, 4CK5, 4CK6, 4CK7, 4ZCA, 4ZHI
Identifiers
Aliases	KIF11, EG5, HKSP, KNSL1, MCLMR, TRIP5, Kinesin family member 11
External IDs	OMIM: 148760; MGI: 1098231; HomoloGene: 3322; GeneCards: KIF11; OMA:KIF11 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	92,655,395 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	37,410,307 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; secondary oocyte; ; gonad; ; bone marrow; ; testicle; ; trabecular bone; ; bone marrow cells; ; stromal cell of endometrium; ; gingival epithelium;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; thymus; ; epiblast; ; bone marrow; ; primary oocyte; ; zygote; ; secondary oocyte; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; microtubule binding; protein-containing complex binding; plus-end-directed microtubule motor activity; ATP binding; protein kinase binding; ATPase activity;
Cellular component	spindle pole; membrane; kinesin complex; spindle; spindle microtubule; microtubule; cytoskeleton; cytoplasm; cytosol; nucleus; protein-containing complex; mitotic spindle;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of mitotic centrosome separation; chromosome segregation; mitotic spindle organization; cell division; spindle assembly; microtubule-based movement; mitotic spindle assembly; spindle organization; mitotic centrosome separation; cell cycle; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	3832
	16551
	ENSG00000138160
	ENSMUSG00000012443
	P52732
	Q6P9P6
	NM_004523
	NM_010615
	NP_004514
	NP_034745
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF11 is a molecular motor protein that is essential in mitosis. In humans it is coded for by the gene KIF11. Kinesin-like protein KIF11 is a member of the kinesin superfamily, which are nanomotors that move along microtubule tracks in the cell. Named from studies in the early days of discovery, it is also known as Kinesin-5, or as BimC, Eg5 or N-2, based on the founding members of this kinesin family.

Currently, there are over 70 different eukaryotic kinesin-5 proteins identified by sequence similarity. Members of this protein family are known to be involved in various kinds of spindle dynamics and essential for mitosis. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. The human kinesin-5 protein has been actively studied for its role in mitosis and its potential as a therapeutic target for cancer.