KIF2C

KIF2C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HEH, 4UBF, 4Y05
Identifiers
Aliases	KIF2C, CT139, KNSL6, MCAK, kinesin family member 2C
External IDs	OMIM: 604538; MGI: 1921054; HomoloGene: 21355; GeneCards: KIF2C; OMA:KIF2C - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	44,767,767 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	117,039,836 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; right testis; ; left testis; ; sperm; ; embryo; ; ganglionic eminence; ; gonad; ; testicle; ; bone marrow;
	Top expressed in
	otic placode; ; seminiferous tubule; ; otic vesicle; ; primary oocyte; ; saccule; ; primitive streak; ; maxillary prominence; ; spermatid; ; endothelial cell of lymphatic vessel; ; mandibular prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; microtubule binding; microtubule plus-end binding; centromeric DNA binding; ATPase activity; protein binding; ATP binding; microtubule motor activity;
Cellular component	cytoplasm; membrane; kinesin complex; microtubule cytoskeleton; chromosome; microtubule plus-end; cytoplasmic microtubule; chromosome, centromeric region; cytoskeleton; microtubule; nucleus; kinetochore; nucleoplasm; centrosome; cytosol;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; establishment or maintenance of microtubule cytoskeleton polarity; chromosome segregation; cell division; regulation of chromosome segregation; microtubule-based movement; cell cycle; microtubule depolymerization; mitotic metaphase plate congression; cell population proliferation; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; sister chromatid cohesion; metaphase plate congression; attachment of mitotic spindle microtubules to kinetochore; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	11004
	73804
	ENSG00000142945
	ENSMUSG00000028678
	Q99661
	Q922S8
	NM_001297655; NM_001297656; NM_001297657; NM_006845
	NM_001290662; NM_134471
	NP_001284584; NP_001284585; NP_001284586; NP_006836
	NP_001277591; NP_608301
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

The protein encoded by this gene is a member of kinesin-like protein family, and contains common ATPase site structures such as the P-loop, Switch 1, and Switch 2. Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.