Killer cell immunoglobulin-like receptor 2DL3

KIR2DL3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1B6U
Identifiers
Aliases	KIR2DL3, CD158B2, CD158b, GL183, KIR-023GB, KIR-K7b, KIR-K7c, KIR2DS5, KIRCL23, NKAT, NKAT2, NKAT2A, NKAT2B, p58, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3, KIR2DS3, KIR2DL
External IDs	OMIM: 604938; HomoloGene: 130667; GeneCards: KIR2DL3; OMA:KIR2DL3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,753,052 bp
RNA expression pattern
	Top expressed in
	testicle; ; granulocyte; ; blood; ; spleen; ; bone marrow; ; right lung; ; endometrium; ; placenta; ; upper lobe of left lung; ; olfactory zone of nasal mucosa;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	antigen binding; protein binding; signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	immune response; regulation of immune response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	3804
	n/a
ENSG00000283708; ENSG00000274830; ENSG00000283790; ENSG00000277554; ENSG00000274952;
	ENSG00000284504; ENSG00000278369; ENSG00000278327; ENSG00000284510; ENSG00000277924; ENSG00000276459; ENSG00000283702; ENSG00000274402; ENSG00000284241; ENSG00000277484; ENSG00000273887; ENSG00000275623; ENSG00000243772; ENSG00000276218; ENSG00000275658; ENSG00000273947; ENSG00000274108; ENSG00000284333; ENSG00000284044; ENSG00000277317; ENSG00000284236; ENSG00000284132; ENSG00000276590; ENSG00000275008; ENSG00000274410; ENSG00000283996
	n/a
	P43628
	n/a
	NM_015868; NM_014511
	n/a
	NP_056952
	n/a
	Wikidata
View/Edit Human

KIR2DL3, Killer cell immunoglobulin-like receptor 2DL3 is a transmembrane glycoprotein expressed by the natural killer cells and the subsets of the T cells. The KIR genes are polymorphic, which means that they have many different alleles. The KIR genes are also extremely homologous, which means that they are similar in position, structure and evolutionary origin, but not necessarily in function.

Natural killer (NK) cells are an important component of innate antiviral immune response. Have the ability to lyse target cells without prior sensitization antigen and regulate the immune responses by secreting chemokine adaptive and cytokines. Activation of NK cells is determined by integration of inhibitory signals and activating issued by several families of different receptors, including killer cell immunoglobulin-like receptors (KIR) that predominantly recognize antigens of class I human leukocyte antigen ( HLA).