KLF13

KLF13
Identifiers
Aliases	KLF13, BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1, Kruppel-like factor 13, Kruppel like factor 13
External IDs	OMIM: 605328; MGI: 1354948; HomoloGene: 32288; GeneCards: KLF13; OMA:KLF13 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	31,435,665 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	63,588,663 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; granulocyte; ; right lung; ; mucosa of transverse colon; ; right frontal lobe; ; left lobe of thyroid gland; ; body of pancreas; ; right lobe of thyroid gland; ; monocyte; ; ganglionic eminence;
	Top expressed in
	Rostral migratory stream; ; molar; ; thymus; ; granulocyte; ; blood; ; ankle; ; hair follicle; ; mesenteric lymph nodes; ; external carotid artery; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; negative regulation of erythrocyte differentiation; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	51621
	50794
	ENSG00000169926; ENSG00000275746
	ENSMUSG00000052040
	Q9Y2Y9
	Q9JJZ6
	NM_001302461; NM_015995
	NM_021366
	NP_001289390; NP_057079
	NP_067341
	Wikidata
View/Edit Human	View/Edit Mouse

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.

There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes. Ghrelin levels also positively correlated with methylation levels of cg07814318. Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.