Kelch-like protein 20

KLHL20
Identifiers
Aliases	KLHL20, KHLHX, KLEIP, KLHLX, kelch like family member 20
External IDs	OMIM: 617679; MGI: 2444855; HomoloGene: 8699; GeneCards: KLHL20; OMA:KLHL20 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	173,786,692 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	160,959,081 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; tendon of biceps brachii; ; sperm; ; gonad; ; nipple; ; popliteal artery; ; tibial arteries; ; ventricular zone; ; gallbladder;
	Top expressed in
	facial motor nucleus; ; tail of embryo; ; endothelial cell of lymphatic vessel; ; cumulus cell; ; anterior horn of spinal cord; ; blood; ; genital tubercle; ; granulocyte; ; trigeminal ganglion; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; interferon-gamma binding; actin binding;
Cellular component	nucleus; cell projection; actin cytoskeleton; Cul3-RING ubiquitin ligase complex; perinuclear region of cytoplasm; dendrite; trans-Golgi network; axon; cytoplasm; Golgi apparatus; PML body; cytosol;
Biological process	Golgi to endosome transport; protein K33-linked ubiquitination; cytoskeleton organization; protein transport; proteasome-mediated ubiquitin-dependent protein catabolic process; response to interferon-alpha; protein ubiquitination; negative regulation of apoptotic process; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	27252
	226541
	ENSG00000076321
	ENSMUSG00000026705
	Q9Y2M5
	Q8VCK5
	NM_014458
	NM_001039482; NM_144876
	NP_055273
	NP_001034571
	Wikidata
View/Edit Human	View/Edit Mouse

Kelch-like protein 20 is a protein that in humans is encoded by the KLHL20 gene.

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities.