KLHL28

KLHL28
Identifiers
Aliases	KLHL28, BTBD5, kelch like family member 28
External IDs	MGI: 1913939; HomoloGene: 23036; GeneCards: KLHL28; OMA:KLHL28 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	45,042,322 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	65,012,308 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; pancreatic epithelial cell; ; mucosa of ileum; ; visceral pleura; ; parietal pleura; ; gingival epithelium; ; deltoid muscle; ; tibialis anterior muscle; ; middle temporal gyrus;
	Top expressed in
	olfactory epithelium; ; Rostral migratory stream; ; trigeminal ganglion; ; otolith organ; ; utricle; ; hand; ; spermatid; ; medial ganglionic eminence; ; epithelium of lens; ; Region I of hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity;
Cellular component	Cul3-RING ubiquitin ligase complex;
Biological process	protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	54813
	66689
	ENSG00000179454
	ENSMUSG00000020948
	Q9NXS3
	Q9CR40
	NM_001308112; NM_017658
	NM_025707
	NP_001295041; NP_060128
	NP_079983
	Wikidata
View/Edit Human	View/Edit Mouse

Kelch-like Homolog 28 (KLHL28) is a protein that is encoded by the KLHL28 gene in humans. It is a member of the Kelch-like gene family, which comprises 42 different genes. Aberrant activation of KLHL28 results in increased likelihood of hypertension, hyperkalemia, and cancer. The KLHL28 gene, also known as BTBD5, has orthologs in vertebrates and some marine invertebrates, and has been well-conserved over evolutionary timescales.