Kelch-like protein 3

KLHL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CH9, 4HXI
Identifiers
Aliases	KLHL3, PHA2D, kelch like family member 3
External IDs	OMIM: 605775; MGI: 2445185; HomoloGene: 79542; GeneCards: KLHL3; OMA:KLHL3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	137,736,089 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	58,261,406 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; middle temporal gyrus; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; cardiac muscle tissue of right atrium; ; Brodmann area 23; ; Brodmann area 46; ; sural nerve; ; Region I of hippocampus proper; ; inferior olivary nucleus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; hippocampus proper; ; primary visual cortex; ; human kidney; ; superior frontal gyrus; ; olfactory bulb; ; Cerebellum; ; striatum of neuraxis; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin binding; protein binding; structural molecule activity; ubiquitin-protein transferase activity;
Cellular component	cytoplasm; cytoskeleton; Cul3-RING ubiquitin ligase complex; cytosol;
Biological process	protein K48-linked ubiquitination; distal tubule morphogenesis; renal sodium ion absorption; protein ubiquitination; ion homeostasis; post-translational protein modification; ubiquitin-dependent protein catabolic process; selective autophagy;
	Sources:Amigo / QuickGO
Orthologs
	26249
	100503085
	ENSG00000146021
	ENSMUSG00000014164
	Q9UH77
	E0CZ16
	NM_017415; NM_001257194; NM_001257195
	NM_001195075; NM_001362415; NM_001368867; NM_001368868
	NP_001244123; NP_001244124; NP_059111
	NP_001349344; NP_001355796; NP_001355797
	Wikidata
View/Edit Human	View/Edit Mouse

Kelch-like protein 3 is a protein in humans that is encoded by the KLHL3 gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms.