KLK4

KLK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BDG, 2BDH, 2BDI, 4K1E, 4K8Y, 4KEL, 4KGA
Identifiers
Aliases	KLK4, AI2A1, ARM1, EMSP, EMSP1, KLK-L1, PRSS17, PSTS, kallikrein, kallikrein related peptidase 4
External IDs	OMIM: 603767; MGI: 1861379; HomoloGene: 55856; GeneCards: KLK4; OMA:KLK4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,911,395 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,535,228 bp
RNA expression pattern
	Top expressed in
	prostate; ; mucosa of transverse colon; ; testicle; ; skin of leg; ; skin of abdomen; ; gonad; ; salivary gland; ; minor salivary glands; ; left lobe of thyroid gland; ; canal of the cervix;
	Top expressed in
	molar; ; decidua; ; thymus; ; muscle; ; rhombencephalon; ; pituitary gland; ; adipose tissue; ; brown adipose tissue; ; muscle tissue; ; torso;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; metal ion binding; serine-type endopeptidase activity;
Cellular component	extracellular region; secretory granule;
Biological process	proteolysis; amelogenesis; biomineral tissue development; extracellular matrix disassembly;
	Sources:Amigo / QuickGO
Orthologs
	9622
	56640
	ENSG00000167749
	ENSMUSG00000006948
	Q9Y5K2
	Q9Z0M1
	NM_001302961; NM_004917
	NM_019928
	NP_001289890; NP_004908
	NP_064312
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In particular, they may serve as biomarkers for both prostate cancer and breast cancer.

This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined.