KLK6

KLK6
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1GVL, 1L2E, 1LO6, 3VFE, 4D8N
Identifiers
Aliases	KLK6, Bssp, Klk7, PRSS18, PRSS9, SP59, hK6, kallikrein related peptidase 6
External IDs	OMIM: 602652; MGI: 1343166; HomoloGene: 68279; GeneCards: KLK6; OMA:KLK6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,969,673 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,481,454 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; inferior ganglion of vagus nerve; ; inferior olivary nucleus; ; middle frontal gyrus; ; Pons; ; corpus callosum; ; optic nerve; ; subthalamic nucleus; ; substantia nigra; ; pars reticulata;
	Top expressed in
	lip; ; lumbar subsegment of spinal cord; ; deep cerebellar nuclei; ; anterior horn of spinal cord; ; pontine nuclei; ; cerebellar cortex; ; skin of external ear; ; motor neuron; ; white matter; ; Medulla Oblongata;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; extracellular region; nucleolus; endoplasmic reticulum; mitochondrion; nucleus; extracellular space; secretory granule;
Biological process	neuron death; regulation of neuron projection development; tissue regeneration; amyloid precursor protein metabolic process; protein autoprocessing; proteolysis; central nervous system development; positive regulation of G protein-coupled receptor signaling pathway; response to wounding; collagen catabolic process; regulation of cell differentiation; myelination; hormone metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5653
	19144
	ENSG00000167755
	ENSMUSG00000050063
	Q92876
	n/a
	NM_002774; NM_001012964; NM_001012965; NM_001319948; NM_001319949
	NM_001164696; NM_001164697; NM_001164698; NM_011177
	NP_001012982; NP_001012983; NP_001306877; NP_001306878; NP_002765
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene. Kallikrein-6 is also referred to as neurosin, protease M, hK6, or zyme. It is a 223 amino acid sequence, derived from its 244 original form, which contains a 16 residue presignal and 5 residue activation peptide.