KLK7

KLK7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QXG, 2QXH, 2QXI, 2QXJ, 3BSQ
Identifiers
Aliases	KLK7, PRSS6, SCCE, hK7, kallikrein related peptidase 7
External IDs	OMIM: 604438; MGI: 1346336; HomoloGene: 37998; GeneCards: KLK7; OMA:KLK7 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,984,099 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,465,783 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; vulva; ; human penis; ; skin of arm; ; skin of thigh; ; skin of abdomen; ; nipple; ; skin of hip; ; mucosa of pharynx; ; body of tongue;
	Top expressed in
	lip; ; skin of external ear; ; basilar part of occipital bone; ; skin of back; ; esophagus; ; sphenoid bone; ; decidua; ; umbilical cord; ; basisphenoid; ; Meckel's cartilage;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity; metalloendopeptidase activity;
Cellular component	extracellular region; epidermal lamellar body; extracellular space; secretory granule;
Biological process	positive regulation of antibacterial peptide production; extracellular matrix disassembly; proteolysis; epidermis development;
	Sources:Amigo / QuickGO
Orthologs
	5650
	23993
	ENSG00000169035
	ENSMUSG00000030713
	P49862; Q6DTY1
	Q91VE3
	NM_139277; NM_001207053; NM_001243126; NM_005046
	NM_011872
	NP_001193982; NP_001230055; NP_005037; NP_644806
	NP_036002
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme (SCCE). It was later identified as the seventh member of the human kallikrein family, which includes fifteen homologous serine proteases located on chromosome 19 (19q13).