KLK8

KLK8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NPM
Identifiers
Aliases	KLK8, HNP, NP, NRPN, PRSS19, TADG14, kallikrein related peptidase 8
External IDs	OMIM: 605644; MGI: 1343327; HomoloGene: 21410; GeneCards: KLK8; OMA:KLK8 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,002,711 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,453,250 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; testicle; ; right uterine tube; ; vagina; ; human penis; ; oral cavity; ; minor salivary glands; ; vulva; ; gonad;
	Top expressed in
	lip; ; esophagus; ; superior surface of tongue; ; skin of external ear; ; vas deferens; ; embryo; ; embryo; ; epiblast; ; skin of abdomen; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; protein binding; hydrolase activity;
Cellular component	cytoplasm; extracellular region; extracellular space; serine protease inhibitor complex; secretory granule;
Biological process	synapse organization; keratinocyte proliferation; negative regulation of axon regeneration; neuron projection morphogenesis; cell death; memory; response to wounding; negative regulation of myelination; regulation of synapse organization; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	11202
	259277
	ENSG00000129455
	ENSMUSG00000064023
	O60259
	Q61955
	NM_001281431; NM_007196; NM_144505; NM_144506; NM_144507
	NM_008940; NM_001324398
	NP_001268360; NP_009127; NP_653088; NP_653089; NP_653090
	NP_001311327; NP_032966
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.