Plasma kallikrein

Plasma kallikrein
Identifiers
EC no.3.4.21.34
CAS no.410538-33-9
Alt. namesserum kallikrein, kininogenin, kallikrein I, kallikrein II, kininogenase, kallikrein, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, panceatic kallikrein, onokrein P, dilminal D, depot-Padutin, urokallikrein, urinary kallikrein
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
KLKB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLKB1, KLK3, PPK, PKKD, PKK, kallikrein B1
External IDsOMIM: 229000; MGI: 102849; HomoloGene: 68097; GeneCards: KLKB1; OMA:KLKB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3818

16621

Ensembl

ENSG00000164344

ENSMUSG00000109764

UniProt

P03952

P26262

RefSeq (mRNA)

NM_000892
NM_001318394
NM_001318396

NM_008455

RefSeq (protein)

NP_000883
NP_001305323
NP_001305325

NP_032481

Location (UCSC)Chr 4: 186.21 – 186.26 MbChr 8: 45.72 – 45.75 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Plasma kallikrein (EC 3.4.21.34) is an enzyme that catalyses the following chemical reaction:

Selective cleavage of some Arg- and Lys- bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin

Plasma kallikrein and its precursor are encoded by the KLKB1 gene.

This enzyme is formed from prekallikrein (Fletcher factor) by factor XIIa.