KLRD1

KLRD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B6E, 3BDW, 3CDG, 3CII
Identifiers
Aliases	KLRD1, CD94, killer cell lectin like receptor D1
External IDs	OMIM: 602894; MGI: 1196275; HomoloGene: 1705; GeneCards: KLRD1; OMA:KLRD1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,329,608 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	129,575,738 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; bone marrow; ; lymph node; ; bone marrow cells; ; upper lobe of left lung; ; testicle; ; mononuclear cell; ; gonad;
	Top expressed in
	blood; ; spleen; ; mesenteric lymph nodes; ; subcutaneous adipose tissue; ; thymus; ; jejunum; ; duodenum; ; granulocyte; ; bone marrow; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein antigen binding; MHC class Ib protein binding, via antigen binding groove; protein binding; transmembrane signaling receptor activity; MHC class I protein complex binding; carbohydrate binding;
Cellular component	integral component of membrane; receptor complex; plasma membrane; membrane; external side of plasma membrane;
Biological process	cell surface receptor signaling pathway; innate immune response; natural killer cell mediated immunity; regulation of immune response;
	Sources:Amigo / QuickGO
Orthologs
	3824
	16643
	ENSG00000134539
	ENSMUSG00000030165
	Q13241
	O54707
NM_001114396; NM_002262; NM_007334; NM_001351060; NM_001351062;
	NM_001351063
	NM_010654
NP_001107868; NP_002253; NP_031360; NP_001337989; NP_001337991;
	NP_001337992
	NP_034784
	Wikidata
View/Edit Human	View/Edit Mouse

CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene.

The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.