NKG2D

KLRK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KCG, 4PDC, 1HYR, 1MPU, 4S0U
Identifiers
Aliases	KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D, natural killer group 2D, killer cell lectin-like receptor K1, killer cell lectin like receptor K1
External IDs	OMIM: 611817; MGI: 1196250; HomoloGene: 136440; GeneCards: KLRK1; OMA:KLRK1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,391,874 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	129,600,827 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; lymph node; ; blood; ; appendix; ; gallbladder; ; upper lobe of left lung; ; mucosa of transverse colon; ; bone marrow; ; testicle;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; plantaris muscle; ; extensor digitorum longus muscle; ; morula; ; spleen; ; corneal stroma; ; mesenteric lymph nodes; ; granulocyte; ; interventricular septum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; protein binding; MHC class Ib receptor activity; MHC class I protein binding; carbohydrate binding; signaling receptor activity; kinase binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; cell surface; external side of plasma membrane; plasma membrane;
Biological process	cell differentiation; adaptive immune response; immune system process; positive regulation of nitric oxide biosynthetic process; negative regulation of natural killer cell chemotaxis; T cell costimulation; natural killer cell activation; positive regulation of interferon-gamma production; stimulatory C-type lectin receptor signaling pathway; negative regulation of GTPase activity; regulation of immune response; cellular response to lipopolysaccharide; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; defense response to Gram-positive bacterium; innate immune response; natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of myeloid dendritic cell activation; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	22914
	27007
	ENSG00000213809
	ENSMUSG00000030149
	P26718
	O54709
	NM_007360
	NM_001083322; NM_001286018; NM_033078
	NP_001186734
	NP_001076791; NP_001272947; NP_149069
	Wikidata
View/Edit Human	View/Edit Mouse

NKG2D is an activating receptor (transmembrane protein) belonging to the NKG2 family of C-type lectin-like receptors. NKG2D is encoded by KLRK1 (killer cell lectin like receptor K1) gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice and chromosome 12 in humans. In mice, it is expressed by NK cells, NK1.1⁺ T cells, γδ T cells, activated CD8⁺ αβ T cells and activated macrophages. In humans, it is expressed by NK cells, γδ T cells and CD8⁺ αβ T cells. NKG2D recognizes induced-self proteins from MIC and RAET1/ULBP families which appear on the surface of stressed, malignant transformed, and infected cells.