KMT5A

KMT5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZKK, 2BQZ, 3F9W, 3F9X, 3F9Y, 3F9Z, 4IJ8, 5HQ2
Identifiers
Aliases	KMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET07
External IDs	OMIM: 607240; MGI: 1915206; HomoloGene: 41372; GeneCards: KMT5A; OMA:KMT5A - orthologs
EC number	2.1.1.354
Gene location (Human)
Chr.	Chromosome 12 (human)
End	123,409,353 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	124,600,371 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ventricular zone; ; right coronary artery; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; Achilles tendon; ; right lobe of thyroid gland; ; body of pancreas; ; popliteal artery;
	Top expressed in
	tail of embryo; ; genital tubercle; ; gastrula; ; granulocyte; ; muscle of thigh; ; pyloric antrum; ; zygote; ; lip; ; knee joint; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-lysine N-methyltransferase activity; methyltransferase activity; transcription corepressor activity; p53 binding; protein binding; transferase activity; lysine N-methyltransferase activity; histone-lysine N-methyltransferase activity; histone methyltransferase activity (H4-K20 specific);
Cellular component	nucleus; nucleoplasm; chromosome; cytosol;
Biological process	methylation; regulation of transcription, DNA-templated; peptidyl-lysine monomethylation; cell cycle; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; cell division; transcription, DNA-templated; regulation of DNA damage response, signal transduction by p53 class mediator; histone lysine methylation; regulation of signal transduction by p53 class mediator; histone H4-K20 methylation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	387893
	67956
	ENSG00000183955
	ENSMUSG00000049327
	Q9NQR1
	Q2YDW7
NM_020382; NM_001324504; NM_001324505; NM_001324506; NM_001367386;
	NM_001367388; NM_001367389
	NM_030241; NM_001310723; NM_001310725; NM_001310727
NP_001311433; NP_001311434; NP_001311435; NP_065115; NP_001354315;
	NP_001354317; NP_001354318
NP_001297652; NP_001297654; NP_001297656; NP_084517; NP_001392317;
	NP_001392319
	Wikidata
View/Edit Human	View/Edit Mouse

N-lysine methyltransferase KMT5A is an enzyme that in humans is encoded by the KMT5A gene. The enzyme is a histone methyltransferase, SET domain-containing and lysine-specific. The enzyme transfers one methyl group to histone H4 lysine residue at position 20. S-Adenosyl methionine (SAM) is both the cofactor and the methyl group donor. The lysine residue is converted to N⁶-methyllysine residue.

This histone modification is often abbreviated H4K20me1:

H4 - type of histone
K - symbol of lysine
20 - position of the lysine residue modified
me - abbreviation for methyl group
1 - number of methyl groups transferred