High-molecular-weight kininogen
| kininogen 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | KNG1 | ||||||
| Alt. symbols | KNG, BDK | ||||||
| NCBI gene | 3827 | ||||||
| HGNC | 6383 | ||||||
| OMIM | 612358 | ||||||
| RefSeq | NM_001102416 | ||||||
| UniProt | P01042 | ||||||
| Other data | |||||||
| Locus | Chr. 3 q21-qter | ||||||
| |||||||
High-molecular-weight kininogen (HMWK or HK) is a circulating plasma protein which participates in the initiation of blood coagulation, and in the generation of the vasodilator bradykinin via the kallikrein-kinin system. HMWK is inactive until it either adheres to binding proteins beneath an endothelium disrupted by injury, thereby initiating coagulation; or it binds to intact endothelial cells or platelets for functions other than coagulation.