KREMEN1

KREMEN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5FWS, 5FWT, 5FWV
Identifiers
Aliases	KREMEN1, KREMEN, KRM1, kringle containing transmembrane protein 1, ECTD13
External IDs	OMIM: 609898; MGI: 1933988; HomoloGene: 12935; GeneCards: KREMEN1; OMA:KREMEN1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	29,168,333 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,211,558 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; decidua; ; parotid gland; ; cardiac muscle tissue of right atrium; ; vena cava; ; tibialis anterior muscle; ; myocardium of left ventricle; ; gingival epithelium; ; Skeletal muscle tissue of rectus abdominis; ; body of tongue;
	Top expressed in
	interventricular septum; ; lip; ; muscle layer of urethra; ; thymus; ; vestibular membrane of cochlear duct; ; muscle of thigh; ; soleus muscle; ; ascending aorta; ; aortic valve; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; soma;
Biological process	regulation of canonical Wnt signaling pathway; cell communication; Wnt signaling pathway; apoptotic process; negative regulation of ossification; limb development; negative regulation of canonical Wnt signaling pathway; negative regulation of axon regeneration;
	Sources:Amigo / QuickGO
Orthologs
	83999
	84035
	ENSG00000183762
	ENSMUSG00000020393
	Q96MU8
	Q99N43
	NM_001039570; NM_032045; NM_153379
	NM_032396
	NP_001034659; NP_114434
	NP_115772
	Wikidata
View/Edit Human	View/Edit Mouse

Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene. Kremen1 is conserved in chordates including amphioxus and most vertebrate species. The protein is a type I transmembrane receptor of ligands Dickkopf1, Dickkopf2, Dickkopf3, Dickkopf4, EpCAM and Rspondin1.