Keratin 16

KRT16
Identifiers
Aliases	KRT16, CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1, keratin 16
External IDs	OMIM: 148067; MGI: 96690; HomoloGene: 21145; GeneCards: KRT16; OMA:KRT16 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,615,899 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,139,728 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; hair follicle; ; buccal mucosa cell; ; amniotic fluid; ; skin of abdomen; ; skin of leg; ; periodontal fiber; ; cervix epithelium; ; body of tongue; ; epithelium of esophagus;
	Top expressed in
	lip; ; middle ear; ; epidermis; ; Eustachian tube; ; zone of skin; ; olfactory system; ; corneal epithelium; ; urethra; ; vagina; ; mandibular molars;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of cytoskeleton; protein binding; structural molecule activity;
Cellular component	extracellular exosome; cytoskeleton; intermediate filament; nucleus; cytosol;
Biological process	morphogenesis of an epithelium; hair cycle; keratinocyte migration; ageing; cell population proliferation; inflammatory response; negative regulation of cell migration; innate immune response; cytoskeleton organization; keratinocyte differentiation; epidermis development; intermediate filament cytoskeleton organization; establishment of skin barrier; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3868
	16666
	ENSG00000186832
	ENSMUSG00000053797
	P08779
	Q9Z2K1
	NM_005557
	NM_008470; NM_001313958
	NP_005548
	NP_001300887; NP_032496
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.

Keratin 16 is a type I cytokeratin. It is paired with keratin 6 in a number of epithelial tissues, including nail bed, esophagus, tongue, and hair follicles. Mutations in the gene encoding this protein are associated with the genetic skin disorders including pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.