Keratin 17

KRT17
Identifiers
Aliases	KRT17, K17, PC, PC2, PCHC1, 39.1, CK-17, keratin 17
External IDs	OMIM: 148069; MGI: 96691; HomoloGene: 363; GeneCards: KRT17; OMA:KRT17 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,624,842 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,151,855 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; olfactory zone of nasal mucosa; ; amniotic fluid; ; vulva; ; skin of thigh; ; hair follicle; ; skin of arm; ; skin of abdomen; ; nipple; ; buccal mucosa cell;
	Top expressed in
	lip; ; molar; ; skin of back; ; epidermis; ; hair follicle; ; skin of external ear; ; skin of abdomen; ; thymus; ; corneal stroma; ; hair;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton; MHC class II receptor activity; protein binding; structural molecule activity; MHC class II protein binding;
Cellular component	cytoplasm; extracellular exosome; intermediate filament; cell periphery; cytosol; intermediate filament cytoskeleton;
Biological process	morphogenesis of an epithelium; positive regulation of hair follicle development; hair follicle morphogenesis; intermediate filament organization; positive regulation of cell growth; positive regulation of translation; signal transduction; epidermis development; keratinization; cornification; cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	3872
	16667
	ENSG00000128422
	ENSMUSG00000035557
	Q04695
	Q9QWL7
	NM_000422
	NM_010663
	NP_000413
	NP_034793
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex.