Keratin 4

KRT4
Identifiers
Aliases	KRT4, CK-4, CK4, CYK4, K4, WSN1, Keratin 4
External IDs	OMIM: 123940; MGI: 96701; HomoloGene: 20523; GeneCards: KRT4; OMA:KRT4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,814,116 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,833,170 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; oral cavity; ; body of tongue; ; palpebral conjunctiva; ; superior surface of tongue; ; buccal mucosa cell; ; amniotic fluid; ; nasal epithelium; ; gums; ; epithelium of nasopharynx;
	Top expressed in
	superior surface of tongue; ; esophagus; ; conjunctival fornix; ; condyle; ; molar; ; fossa; ; cornea; ; ciliary body; ; corneal stroma; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; structural molecule activity;
Cellular component	cell surface; intermediate filament cytoskeleton; keratin filament; intermediate filament; nucleus; cytosol;
Biological process	epithelial cell differentiation; cytoskeleton organization; negative regulation of epithelial cell proliferation; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3851
	16682
	ENSG00000170477
	ENSMUSG00000059668
	P19013
	P07744
	NM_002272
	NM_008475
	NP_002263
	NP_032501
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.

Keratin 4 is a type II cytokeratin. It is specifically found in differentiated layers of the mucosal and esophageal epithelia together with keratin 13. Mutations in the genes encoding this protein have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia.