KRT86

KRT86
Identifiers
Aliases	KRT86, HB6, Hb1, KRTHB1, KRTHB6, MNX, hHb6, K86, keratin 86
External IDs	OMIM: 601928; MGI: 109362; HomoloGene: 1717; GeneCards: KRT86; OMA:KRT86 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,309,163 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,377,867 bp
RNA expression pattern
	Top expressed in
	testicle; ; right coronary artery; ; skin of arm; ; buccal mucosa cell; ; hair follicle; ; ascending aorta; ; amniotic fluid; ; left coronary artery; ; tibialis anterior muscle; ; decidua;
	Top expressed in
	lip; ; granulocyte; ; Ileal epithelium; ; embryo; ; entorhinal cortex; ; lactiferous gland; ; skin of back; ; hair follicle; ; skin of abdomen; ; CA3 field;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; structural molecule activity;
Cellular component	keratin filament; extracellular exosome; intermediate filament; extracellular space; cytosol;
Biological process	keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3892
	16679
	ENSG00000170442
	ENSMUSG00000067614
	O43790
	P97861
	NM_002284; NM_001320198
	NM_010667
	NP_001307127
	NP_034797
	Wikidata
View/Edit Human	View/Edit Mouse

The KRT86 gene encodes for keratin, type II cuticular Hb6 protein in humans.

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRT81, KRT83, and KRT86, is highly related. The other, less-related subfamily includes KRT82, KRT84, and KRT85. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRT81 and KRT83, is found primarily in the hair cortex. Mutations in this gene and KRT81 have been observed in patients with a rare dominant hair disease, monilethrix.