KSR2

KSR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Y4I
Identifiers
Aliases	KSR2, kinase suppressor of ras 2
External IDs	OMIM: 610737; MGI: 3610315; HomoloGene: 45469; GeneCards: KSR2; OMA:KSR2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	117,968,990 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	117,913,068 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; postcentral gyrus; ; endothelial cell; ; entorhinal cortex; ; superior frontal gyrus; ; primary visual cortex; ; buccal mucosa cell; ; cerebellar vermis; ; Brodmann area 46;
	Top expressed in
	zygote; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; secondary oocyte; ; lumbar subsegment of spinal cord; ; neural layer of retina; ; hippocampus proper; ; Amygdala;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein serine/threonine kinase activity; ATP binding; metal ion binding; kinase activity; protein kinase activity; signal transducer activity; protein binding;
Cellular component	cytoplasm; membrane; cytosol; plasma membrane;
Biological process	intracellular signal transduction; phosphorylation; protein phosphorylation; Ras protein signal transduction; calcium-mediated signaling; positive regulation of MAPK cascade; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	283455
	333050
	ENSG00000171435
	ENSMUSG00000061578
	Q6VAB6
	Q3UVC0
	NM_173598
	NM_001034873; NM_001114545; NM_001312914
	NP_775869
	NP_001299843
	Wikidata
View/Edit Human	View/Edit Mouse

KSR2 is a gene which encodes Kinase Suppressor of Ras 2 in humans.

The encoded protein plays a role in energy homeostasis, including fatty acid oxidation, glucose metabolism and basal metabolic rate (BMR). As a result, subsequent mutations in this gene, albeit rare, have been linked to the development of early on-set obesity and insulin resistance.

Variations within the gene and its expression are hypothesized to play a key role in the phenotype of individuals with metabolic disease, alongside leptin-deficiency induced hyperphagia. While the exact mechanism is unclear, it is believed that KSR2 variations result in a disruption of the MAPK/ERK pathway, which can in turn lower the body's BMR. Since this normally accounts for about 70% of the total energy expenditure, a decrease results in excess energy storage, compared to an individual with a normal BMR on an isocaloric diet.

Besides human metabolism, KSR2 is also crucial for ovarian development in the cabbage beetle Colaphellus bowringi.