KYAT1

KYAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W7L, 1W7M, 1W7N, 3FVS, 3FVU, 3FVX, 4WLH, 4WLJ, 4WP0
Identifiers
Aliases	KYAT1, GTK, KAT1, KATI, CCBL1, kynurenine aminotransferase 1
External IDs	OMIM: 600547; MGI: 1917516; HomoloGene: 37872; GeneCards: KYAT1; OMA:KYAT1 - orthologs
EC number	4.4.1.13
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	30,095,859 bp
RNA expression pattern
	n/a
	Top expressed in
	esophagus; ; right kidney; ; lip; ; left lobe of liver; ; human kidney; ; middle ear; ; Eustachian tube; ; salivary gland; ; seminal vesicula; ; parotid gland;
	More reference expression data
Gene ontology
Molecular function	transferase activity; kynurenine-oxoglutarate transaminase activity; protein homodimerization activity; L-glutamine:pyruvate aminotransferase activity; transaminase activity; glutamine-phenylpyruvate transaminase activity; protein binding; catalytic activity; lyase activity; L-phenylalanine:pyruvate aminotransferase activity; pyridoxal phosphate binding; L-glutamine aminotransferase activity; cysteine-S-conjugate beta-lyase activity;
Cellular component	nucleoplasm; cytoplasm; cytosol; mitochondrion;
Biological process	L-phenylalanine catabolic process; cellular amino acid biosynthetic process; biosynthesis; L-kynurenine catabolic process; tryptophan catabolic process; cellular modified amino acid metabolic process; kynurenine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	883
	70266
	ENSG00000171097
	ENSMUSG00000039648
	Q16773
	Q8BTY1
	NM_001122671; NM_001122672; NM_001287390; NM_004059
	NM_172404; NM_001356474; NM_001356475
NP_001116143; NP_001116144; NP_001274319; NP_004050; NP_001339917;
	NP_001339918; NP_001339919; NP_001339920; NP_001339921; NP_001339922; NP_001339923; NP_001339924; NP_001339925; NP_001339926; NP_001339927; NP_001339928
	NP_765992; NP_001343403; NP_001343404
	Wikidata
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Kynurenine—oxoglutarate transaminase 1 is an enzyme that in humans is encoded by the CCBL1 gene. It is one of the Kynurenine—oxoglutarate transaminases.

This gene encodes a cytosolic enzyme which is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism leads to the formation of reactive metabolites which can lead to nephrotoxicity and neurotoxicity.