Karl I, Prince of Anhalt-Zerbst
| Karl I | |
|---|---|
| Prince of Anhalt-Zerbst | |
| Reign | 1551–1561 |
| Predecessor | John V |
| Successor | Joachim Ernest and Bernhard VII |
| Prince of Anhalt-Plötzkau | |
| Reign | 1553–1561 |
| Predecessor | George III |
| Successor | Joachim Ernest and Bernhard VII |
| Born | 17 November 1534 Dessau |
| Died | 4 May 1561 Zerbst |
| Spouse | Anna of Pomerania |
| House | House of Ascania |
| Father | John V, Prince of Anhalt-Zerbst |
| Mother | Margaret of Brandenburg |
Karl I of Anhalt-Zerbst (17 November 1534 – 4 May 1561), was a German prince of the House of Ascania and ruler of the principality of Anhalt-Zerbst.
He was the eldest son of John V, Prince of Anhalt-Zerbst, by his wife Margaret, daughter of Joachim I Nestor, Elector of Brandenburg.