Keratin 2A

KRT2
Identifiers
Aliases	KRT2, CK-2e, K2e, KRT2A, KRT2E, KRTE, keratin 2
External IDs	OMIM: 600194; MGI: 96699; HomoloGene: 30974; GeneCards: KRT2; OMA:KRT2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,652,211 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,726,604 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of thigh; ; skin of hip; ; skin of abdomen; ; nipple; ; human penis; ; gingival epithelium; ; vulva; ; palpebral conjunctiva; ; gastrocnemius muscle;
	Top expressed in
	skin of external ear; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; ankle; ; ankle joint; ; Ileal epithelium; ; entorhinal cortex; ; filiform papilla; ; stellate ganglion; ; ganglion of vagus nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of cytoskeleton; protein binding; structural molecule activity; cytoskeletal protein binding; structural constituent of skin epidermis;
Cellular component	keratin filament; extracellular exosome; membrane; nucleus; intermediate filament; extracellular space; cytosol; cornified envelope;
Biological process	keratinocyte migration; keratinocyte activation; keratinocyte proliferation; intermediate filament organization; epidermis development; keratinocyte development; keratinization; cornification; peptide cross-linking; positive regulation of epidermis development;
	Sources:Amigo / QuickGO
Orthologs
	3849
	16681
	ENSG00000172867
	ENSMUSG00000064201
	P35908
	Q3TTY5
	NM_000423
	NM_010668
	NP_000414
	NP_034798
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin 2A also known as keratin 2E or keratin 2 is a protein that in humans is encoded by the KRT2A gene.

Keratin 2A is a type II cytokeratin. It is found largely in the upper spinous layer of epidermal keratinocytes and mutations in the gene encoding this protein have been associated with ichthyosis bullosa of Siemens.