Keratocan

KERA
Identifiers
Aliases	KERA, CNA2, KTN, SLRR2B, keratocan
External IDs	OMIM: 603288; MGI: 1202398; HomoloGene: 5106; GeneCards: KERA; OMA:KERA - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	91,058,024 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	97,449,554 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; testicle; ; cartilage tissue; ; synovial joint; ; tendon of biceps brachii; ; synovial membrane; ; gallbladder; ; lower lobe of lung; ; tibialis anterior muscle; ; trachea;
	Top expressed in
	cornea; ; corneal stroma; ; conjunctival fornix; ; ankle; ; body of femur; ; digastric muscle; ; temporal muscle; ; intercostal muscle; ; triceps brachii muscle; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	molecular function;
Cellular component	Golgi lumen; extracellular region; lysosomal lumen; extracellular space; extracellular matrix;
Biological process	cornea development in camera-type eye; keratan sulfate biosynthetic process; keratan sulfate catabolic process; axonogenesis; response to stimulus; visual perception;
	Sources:Amigo / QuickGO
Orthologs
	11081
	16545
	ENSG00000139330
	ENSMUSG00000019932
	O60938
	O35367
	NM_007035
	NM_008438
	NP_008966
	NP_032464
	Wikidata
View/Edit Human	View/Edit Mouse

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene.

Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican and mimecan, are important to the transparency of the cornea.

Mutations of the gene cause cornea plana 2.