LACTB

LACTB
Identifiers
Aliases	LACTB, G24, MRPL56, lactamase beta
External IDs	OMIM: 608440; MGI: 1933395; HomoloGene: 12755; GeneCards: LACTB; OMA:LACTB - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	63,142,061 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	66,882,766 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; monocyte; ; deltoid muscle; ; pancreatic epithelial cell; ; vastus lateralis muscle; ; tibialis anterior muscle; ; sperm; ; amniotic fluid; ; gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	left lobe of liver; ; proximal tubule; ; interventricular septum; ; right kidney; ; primitive streak; ; human kidney; ; otic vesicle; ; seminal vesicula; ; ciliary body; ; retinal pigment epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; peptidase activity; identical protein binding;
Cellular component	mitochondrion; cytosol;
Biological process	regulation of lipid metabolic process; proteolysis; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	114294
	80907
	ENSG00000103642
	ENSMUSG00000032370
	P83111
	Q9EP89
	NM_001288585; NM_032857; NM_171846
	NM_030717
	NP_001275514; NP_116246; NP_741982
	NP_109642
	Wikidata
View/Edit Human	View/Edit Mouse

Serine beta-lactamase-like protein LACTB, mitochondrial is an enzyme that in humans is encoded by the LACTB gene. This gene encodes a 54 kDa protein sharing significant sequence similarity to serine proteases of the penicillin binding protein and beta-lactamase superfamily occurring in bacteria. It is involved in the regulation of the metabolic circuitry. A causal association has been found between LACTB and obesity. In breast cancer, LACTB has a tumor suppressor function by modulating lipid metabolism.