Laminin, beta 3

LAMB3
Identifiers
Aliases	LAMB3, BM600-125KDA, LAM5, LAMNB1, AI1A, Laminin, beta 3, laminin subunit beta 3, JEB1B, JEB1A
External IDs	OMIM: 150310; MGI: 99915; HomoloGene: 191; GeneCards: LAMB3; OMA:LAMB3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	209,652,425 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	193,026,186 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; periodontal fiber; ; gingival epithelium; ; olfactory zone of nasal mucosa; ; jejunal mucosa; ; mucosa of transverse colon; ; skin of leg; ; mucosa of ileum; ; skin of abdomen; ; mucosa of esophagus;
	Top expressed in
	molar; ; epithelium of stomach; ; left colon; ; granulocyte; ; corneal stroma; ; transitional epithelium of urinary bladder; ; lip; ; left lung; ; mucous cell of stomach; ; lactiferous gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; structural molecule activity; protein-containing complex binding; extracellular matrix structural constituent;
Cellular component	extracellular region; basement membrane; laminin-5 complex; collagen-containing extracellular matrix; laminin complex;
Biological process	hemidesmosome assembly; cell adhesion; extracellular matrix organization; endodermal cell differentiation; brown fat cell differentiation; epidermis development; animal organ morphogenesis; tissue development; cell migration; substrate adhesion-dependent cell spreading; basement membrane assembly;
	Sources:Amigo / QuickGO
Orthologs
	3914
	16780
	ENSG00000196878
	ENSMUSG00000026639
	Q13751
	Q61087
	NM_000228; NM_001017402; NM_001127641
	NM_001277928; NM_008484
	NP_000219; NP_001017402; NP_001121113
	NP_001264857; NP_032510
	Wikidata
View/Edit Human	View/Edit Mouse

Laminin subunit beta-3 is a protein that in humans is encoded by the LAMB3 gene.

LAMB3 encodes the beta 3 subunit of laminin. Laminin is composed of three subunits (alpha, beta, and gamma), and refers to a family of basement membrane proteins. For example, LAMB3 serves as the beta chain in laminin-5. Mutations in LAMB3 have been identified as the cause of various types of epidermolysis bullosa. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.