LAPTM4B

LAPTM4B
Identifiers
Aliases	LAPTM4B, LAPTM4beta, LC27, lysosomal protein transmembrane 4 beta
External IDs	OMIM: 613296; MGI: 1890494; HomoloGene: 10182; GeneCards: LAPTM4B; OMA:LAPTM4B - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	97,853,013 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	34,284,448 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; Epithelium of choroid plexus; ; right ventricle; ; myocardium; ; cardiac muscle tissue of right atrium; ; pancreatic ductal cell; ; myocardium of left ventricle; ; secondary oocyte; ; beta cell; ; biceps brachii;
	Top expressed in
	motor neuron; ; ciliary body; ; Epithelium of choroid plexus; ; facial motor nucleus; ; substantia nigra; ; primary oocyte; ; Paneth cell; ; retinal pigment epithelium; ; medullary collecting duct; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; kinase binding; ubiquitin protein ligase binding; phosphatidylinositol bisphosphate binding; ceramide binding;
Cellular component	endomembrane system; integral component of membrane; membrane; early endosome; multivesicular body, internal vesicle; lysosome; lysosomal membrane; endosome; plasma membrane; endosome membrane; late endosome membrane; multivesicular body membrane; cell projection;
Biological process	endosome organization; endosome transport via multivesicular body sorting pathway; negative regulation of lysosomal protein catabolic process; negative regulation of transforming growth factor beta1 production; regulation of lysosomal membrane permeability; regulation of lysosome organization;
	Sources:Amigo / QuickGO
Orthologs
	55353
	114128
	ENSG00000104341
	ENSMUSG00000022257
	Q86VI4
	Q91XQ6
	NM_018407
	NM_033521
	NP_060877
	NP_277056
	Wikidata
View/Edit Human	View/Edit Mouse

Lysosomal-associated transmembrane protein 4B is a protein that in humans is encoded by the LAPTM4B gene.

LAPTM4B protein contains a lysosome localization motif and localizes on late endosomes and lysosomes.