LARP1

LARP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZC4, 5C0V
Identifiers
Aliases	LARP1, LARP, La ribonucleoprotein domain family member 1, La ribonucleoprotein 1, translational regulator, Lar1, Lhp1
External IDs	OMIM: 612059; MGI: 1890165; HomoloGene: 9089; GeneCards: LARP1; OMA:LARP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	154,817,605 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	57,952,860 bp
RNA expression pattern
	Top expressed in
	superior vestibular nucleus; ; pars reticulata; ; spinal ganglia; ; pars compacta; ; middle temporal gyrus; ; lateral nuclear group of thalamus; ; trigeminal ganglion; ; pylorus; ; Brodmann area 23; ; renal medulla;
	Top expressed in
	primitive streak; ; crypt of lieberkuhn of small intestine; ; lacrimal gland; ; fetal liver hematopoietic progenitor cell; ; epiblast; ; tail of embryo; ; trigeminal ganglion; ; left lobe of liver; ; entorhinal cortex; ; somite;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RNA cap binding; translation activator activity; translation initiation factor binding; protein binding; eukaryotic initiation factor 4E binding; mRNA 3'-UTR binding; mRNA 5'-UTR binding; RNA binding; cadherin binding; RNA 7-methylguanosine cap binding; ribosomal small subunit binding;
Cellular component	cytoplasm; TORC1 complex; membrane; polysome; cytoplasmic stress granule; polysomal ribosome;
Biological process	translational initiation; positive regulation of macroautophagy; positive regulation of viral genome replication; cell population proliferation; TOR signaling; protein biosynthesis; positive regulation of translation; negative regulation of translation; TORC1 signaling; mRNA stabilization; cellular response to rapamycin; response to amino acid starvation; regulation of translation; negative regulation of translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	23367
	73158
	ENSG00000155506
	ENSMUSG00000037331
	Q6PKG0
	Q6ZQ58
NM_015315; NM_033551; NM_001367713; NM_001367714; NM_001367715;
	NM_001367716; NM_001367717; NM_001367718; NM_001367719
	NM_028451
NP_056130; NP_001354642; NP_001354643; NP_001354644; NP_001354645;
	NP_001354646; NP_001354647; NP_001354648; NP_291029
	NP_082727
	Wikidata
View/Edit Human	View/Edit Mouse

La-related protein 1 (LARP1) is a 150 kDa protein that in humans is encoded by the LARP1 gene. LARP1 is a novel target of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, a circuitry often hyperactivated in cancer which regulates cell growth and proliferation primarily through the regulation of protein synthesis.