LARP4

LARP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQK, 3PKN
Identifiers
Aliases	LARP4, PP13296, La ribonucleoprotein domain family member 4
External IDs	MGI: 2443114; HomoloGene: 19173; GeneCards: LARP4; OMA:LARP4 - orthologs
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,914,239 bp
RNA expression pattern
	n/a
	Top expressed in
	tail of embryo; ; genital tubercle; ; morula; ; superior cervical ganglion; ; zygote; ; seminal vesicula; ; hand; ; secondary oocyte; ; parotid gland; ; lacrimal gland;
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; poly(A) binding; RNA binding;
Cellular component	membrane; polysome; cytoplasmic stress granule; cytosolic small ribosomal subunit; cytoplasm; cytosol;
Biological process	regulation of cell morphogenesis; cytoskeleton organization; positive regulation of translation; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	113251
	207214
	ENSG00000161813
	ENSMUSG00000023025
	Q71RC2
	Q8BWW4
NM_001170803; NM_001170804; NM_001170808; NM_052879; NM_199188;
	NM_199190; NM_001330415
	NM_001024526; NM_001080948; NM_001284521; NM_001284522; NM_001284523
NP_001164274; NP_001164275; NP_001164279; NP_001317344; NP_443111;
	NP_954658; NP_954660; NP_001339233; NP_001339234; NP_001339235; NP_001339236; NP_001339237; NP_001339238; NP_001339239; NP_001339240; NP_001339241; NP_001339242; NP_001339243; NP_001339244; NP_001339245; NP_001339246; NP_001339247; NP_001339248; NP_001339249; NP_001339250; NP_001339251; NP_001339252; NP_001339253; NP_001339254; NP_001339255
	NP_001019697; NP_001074417; NP_001271450; NP_001271451; NP_001271452
	Wikidata
View/Edit Human	View/Edit Mouse

La-related protein 4 is a protein that in humans is encoded by the LARP4 gene. LARP4 is an RNA-binding protein which consists of a La motif (LaM), RNA recognition motif (RRM) and a putative PABP binding motif. It has been shown that LARP4 is involved in mRNA stability.

LARP4 is known to regulate cancer cell migration and invasion by altering cell shape. It is also reported to be a glioma tumor suppressor.