LATS1

LATS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZRK, 5BRK, 5B5W
Identifiers
Aliases	LATS1, WARTS, wts, large tumor suppressor kinase 1
External IDs	OMIM: 603473; MGI: 1333883; HomoloGene: 55843; GeneCards: LATS1; OMA:LATS1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	149,718,105 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	7,592,224 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; tibia; ; mucosa of paranasal sinus; ; gingival epithelium; ; epithelium of nasopharynx; ; parietal pleura; ; visceral pleura; ; seminal vesicula; ; retinal pigment epithelium; ; palpebral conjunctiva;
	Top expressed in
	genital tubercle; ; tail of embryo; ; uterus; ; ganglionic eminence; ; ventricular zone; ; ovary; ; lens; ; jejunum; ; granulocyte; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; protein kinase binding; protein kinase activity; kinase activity; transferase activity; metal ion binding; magnesium ion binding; protein serine/threonine kinase activity; ATP binding; estrogen receptor binding;
Cellular component	microtubule organizing center; spindle pole; cytoplasm; cytoskeleton; cytosol;
Biological process	cell cycle; phosphorylation; G2/M transition of mitotic cell cycle; regulation of actin filament polymerization; inner cell mass cell fate commitment; keratinocyte differentiation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of organ growth; regulation of protein-containing complex assembly; cytoplasmic sequestering of protein; sister chromatid segregation; positive regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; inner cell mass cellular morphogenesis; cell division; positive regulation of peptidyl-serine phosphorylation; hippo signaling; protein phosphorylation; hormone-mediated signaling pathway; regulation of intracellular estrogen receptor signaling pathway; mammary gland epithelial cell differentiation; regulation of ubiquitin-dependent protein catabolic process; mitotic cell cycle; G1/S transition of mitotic cell cycle; peptidyl-serine phosphorylation; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9113
	16798
	ENSG00000131023
	ENSMUSG00000040021
	O95835; Q6PJG3
	Q8BYR2
	NM_001270519; NM_004690; NM_001350339; NM_001350340; NM_001350392
	NM_010690
	NP_001257448; NP_004681; NP_001337268; NP_001337269; NP_001337321
	NP_034820
	Wikidata
View/Edit Human	View/Edit Mouse

Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene.

It has been associated with the Hippo signaling pathway, where it phosphorylates YAP and TAZ to inactivate their function.

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced histone H1 kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.