LBH (gene)

LBH
Identifiers
Aliases	LBH, limb bud and heart development, LBH regulator of WNT signaling pathway
External IDs	OMIM: 611763; MGI: 1925139; HomoloGene: 12687; GeneCards: LBH; OMA:LBH - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	30,323,730 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	73,248,942 bp
RNA expression pattern
	Top expressed in
	right lung; ; granulocyte; ; upper lobe of left lung; ; lymph node; ; ascending aorta; ; popliteal artery; ; tibial arteries; ; left ventricle; ; visceral pleura; ; apex of heart;
	Top expressed in
	ascending aorta; ; aortic valve; ; Gonadal ridge; ; molar; ; mesenteric lymph nodes; ; myocardium; ; myocardium of ventricle; ; habenula; ; left lung lobe; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; nucleus; protein-containing complex;
Biological process	multicellular organism development; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; mammary gland development; negative regulation of intracellular estrogen receptor signaling pathway; mammary gland epithelial cell differentiation; positive regulation of somatic stem cell population maintenance; positive regulation of somatic stem cell division; positive regulation of mammary stem cell proliferation; negative regulation of stem cell differentiation; regulation of gene expression; regulation of MAPK cascade; negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	81606
	77889
	ENSG00000213626
	ENSMUSG00000024063
	Q53QV2
	Q9CX60
	NM_030915
	NM_029999
	NP_112177
	NP_084275
	Wikidata
View/Edit Human	View/Edit Mouse

The LBH (Limb Bud-Heart) gene is a highly conserved human gene that produces the LBH protein, a transcription co-factor in the Wnt/β-catenin pathway. Upon transcriptional activation of β-catenin, LBH goes on to act as a regulator of cell proliferation and differentiation through multiple transcriptional targets. The gene is located on the p arm of chromosome 2 and is roughly 28 kb long. Current ongoing studies are examining its role in developmental and oncological settings.