LBX1

LBX1
Identifiers
Aliases	LBX1, HPX-6, HPX6, LBX1H, homeobox, ladybird homeobox 1, CCHS3
External IDs	OMIM: 604255; MGI: 104867; HomoloGene: 4784; GeneCards: LBX1; OMA:LBX1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	101,229,463 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	45,224,251 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; testicle; ; skeletal muscle tissue; ; right hemisphere of cerebellum; ; C1 segment; ; right lung; ; frontal lobe; ; Cortex of frontal lobe; ; dorsolateral prefrontal cortex;
	Top expressed in
	triceps brachii muscle; ; muscle of thigh; ; lumbar subsegment of spinal cord; ; ankle; ; vastus lateralis muscle; ; gastrocnemius muscle; ; tibialis anterior muscle; ; skeletal muscle tissue; ; zygote; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; transcription regulator complex;
Biological process	multicellular organism development; heart looping; anatomical structure morphogenesis; cell differentiation; muscle organ development; neuron fate commitment; spinal cord motor neuron differentiation; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; neuron fate determination; transcription, DNA-templated; nervous system development; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	10660
	16814
	ENSG00000138136
	ENSMUSG00000025216
	P52954
	P52955
	NM_006562
	NM_010691
	NP_006553
	NP_034821
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene.

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes.

In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.