LCMT2

LCMT2
Identifiers
Aliases	LCMT2, PPM2, TYW4, leucine carboxyl methyltransferase 2
External IDs	OMIM: 611246; MGI: 1353659; HomoloGene: 19642; GeneCards: LCMT2; OMA:LCMT2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	43,330,582 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	120,971,134 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; germinal epithelium; ; gingival epithelium; ; kidney tubule; ; glomerulus; ; metanephric glomerulus; ; gonad; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; retinal pigment epithelium;
	Top expressed in
	right kidney; ; proximal tubule; ; otic vesicle; ; right ventricle; ; medullary collecting duct; ; medial ganglionic eminence; ; islet of Langerhans; ; epithelium of stomach; ; primitive streak; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; protein binding; S-adenosylmethionine-dependent methyltransferase activity; tRNA methyltransferase activity; protein C-terminal leucine carboxyl O-methyltransferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	tRNA modification; methylation; tRNA methylation; wybutosine biosynthetic process; tRNA processing; C-terminal protein methylation;
	Sources:Amigo / QuickGO
Orthologs
	9836
	329504
	ENSG00000168806
	ENSMUSG00000074890
	O60294
	Q8BYR1
	NM_014793
	NM_177846
	NP_055608
	NP_808514
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine carboxyl methyltransferase 2 is an enzyme that in humans is encoded by the LCMT2 gene.

The protein encoded by this intronless gene belongs to the methyltransferase superfamily and acts as a G₁/S and G₂/M phase checkpoint regulator. It has been hypothesized that cigarette smoke-induced oxidative stress and transforming growth factor beta 1 may inhibit cellular proliferation by modulating the expression of this protein.