Lipocalin-2

LCN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DFV, 1L6M, 1NGL, 1QQS, 1X71, 1X89, 1X8U, 3BY0, 3CBC, 3CMP, 3DSZ, 3DTQ, 3FW4, 3FW5, 3HWD, 3HWE, 3HWF, 3HWG, 3I0A, 3K3L, 3PEC, 3PED, 3T1D, 3TF6, 3TZS, 3U03, 3U0D, 4GH7, 4IAW, 4IAX, 4K19, 4MVI, 4MVK, 4MVL, 4QAE, 4ZFX, 4ZHC, 4ZHD, 4ZHF, 4ZHG, 4ZHH
Identifiers
Aliases	LCN2, 24p3, MSFI, NGAL, p25, lipocalin 2
External IDs	OMIM: 600181; MGI: 96757; HomoloGene: 4064; GeneCards: LCN2; OMA:LCN2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,153,453 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,278,264 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; nasal epithelium; ; epithelium of bronchus; ; bronchial epithelial cell; ; trabecular bone; ; olfactory zone of nasal mucosa; ; beta cell; ; bone marrow; ; gallbladder; ; bone marrow cells;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; efferent ductule; ; olfactory epithelium; ; lactiferous gland; ; endothelial cell of lymphatic vessel; ; right lung lobe; ; ankle joint; ; cervix; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; small molecule binding; protease binding; iron ion binding; protein homodimerization activity; enterobactin binding;
Cellular component	extracellular exosome; extracellular space; cytosol; specific granule lumen; extracellular region; cytoplasmic vesicle; cytoplasmic vesicle lumen;
Biological process	immune system process; iron ion homeostasis; ion transport; innate immune response; cellular iron ion homeostasis; apoptotic process; response to oxidative stress; response to virus; response to bacterium; response to herbicide; response to mycotoxin; positive regulation of gene expression; siderophore transport; antimicrobial humoral response; positive regulation of cell projection organization; response to nutrient levels; cellular response to nutrient levels; neutrophil degranulation; protein homotrimerization; cellular response to hydrogen peroxide; cellular response to lipopolysaccharide; cellular response to interleukin-1; cellular response to tumor necrosis factor; extrinsic apoptotic signaling pathway in absence of ligand; transport; cytokine-mediated signaling pathway; defense response to bacterium; sequestering of iron ion; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3934
	16819
	ENSG00000148346
	ENSMUSG00000026822
	P80188
	P11672
	NM_005564
	NM_008491
	NP_005555
	NP_032517
	Wikidata
View/Edit Human	View/Edit Mouse

Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), is a protein that in humans is encoded by the LCN2 gene. NGAL is involved in innate immunity by sequestering iron and preventing its use by bacteria, thus limiting their growth. It is expressed in neutrophils and in low levels in the kidney, prostate, and epithelia of the respiratory and alimentary tracts. NGAL is used as a biomarker of kidney injury.