LEO1

LEO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4M6T
Identifiers
Aliases	LEO1, RDL, LEO1 homolog, Paf1/RNA polymerase II complex component
External IDs	OMIM: 610507; MGI: 2685031; HomoloGene: 133895; GeneCards: LEO1; OMA:LEO1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	51,971,778 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	75,373,714 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; ventricular zone; ; mucosa of transverse colon; ; ganglionic eminence; ; oocyte; ; rectum; ; islet of Langerhans; ; Achilles tendon; ; internal globus pallidus; ; secondary oocyte;
	Top expressed in
	otic vesicle; ; tail of embryo; ; genital tubercle; ; neural layer of retina; ; zygote; ; morula; ; hand; ; blastocyst; ; embryo; ; ventricular zone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II C-terminal domain phosphoserine binding; protein binding;
Cellular component	nucleus; centrosome; Cdc73/Paf1 complex; nucleoplasm; fibrillar center;
Biological process	negative regulation of myeloid cell differentiation; positive regulation of mRNA 3'-end processing; mRNA polyadenylation; endodermal cell fate commitment; Wnt signaling pathway; histone H2B ubiquitination; stem cell population maintenance; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; histone monoubiquitination; positive regulation of transcription elongation from RNA polymerase II promoter; histone modification; beta-catenin-TCF complex assembly; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	123169
	235497
	ENSG00000166477
	ENSMUSG00000042487
	Q8WVC0
	Q5XJE5
	NM_001286430; NM_138792; NM_001323903; NM_001323904
	NM_001006122; NM_001039522
	NP_001273359; NP_001310832; NP_001310833; NP_620147
	NP_001034611
	Wikidata
View/Edit Human	View/Edit Mouse

RNA polymerase-associated protein LEO1 is an enzyme that in humans is encoded by the LEO1 gene.