Galectin-9

LGALS9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EAK, 2EAL, 2YY1, 2ZHK, 2ZHL, 2ZHM, 2ZHN, 3LSD, 3LSE, 3NV1, 3NV2, 3NV3, 3NV4, 3WLU, 3WV6
Identifiers
Aliases	LGALS9, HUAT, LGALS9A, galectin 9
External IDs	OMIM: 601879; MGI: 109496; HomoloGene: 32078; GeneCards: LGALS9; OMA:LGALS9 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	27,649,560 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,875,772 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; mucosa of transverse colon; ; rectum; ; gallbladder; ; spleen; ; epithelium of colon; ; lymph node; ; pylorus; ; appendix;
	Top expressed in
	gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach; ; pyloric antrum; ; seminal vesicula; ; left lobe of liver; ; duodenum; ; crypt of lieberkuhn of small intestine; ; thymus; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	galactose binding; signal transducer activity; enzyme binding; disaccharide binding; carbohydrate binding;
Cellular component	intracellular anatomical structure; extracellular region; extracellular exosome; cytoplasm; nucleus; extracellular space; cytosol;
Biological process	negative regulation of interferon-gamma production; response to interleukin-1; toll-like receptor 4 signaling pathway; maternal process involved in female pregnancy; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; immune system process; positive regulation of CD4-positive, alpha-beta T cell proliferation; ERK1 and ERK2 cascade; female pregnancy; positive regulation of viral entry into host cell; positive regulation of monocyte chemotactic protein-1 production; natural killer cell tolerance induction; negative regulation of chemokine production; regulation of interleukin-5 production; toll-like receptor 2 signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; negative regulation of mast cell degranulation; negative regulation of gene expression; positive regulation of interleukin-4 production; chemotaxis; negative regulation of activated T cell proliferation; regulation of interleukin-4 production; response to lipopolysaccharide; positive regulation of gene expression; positive regulation of NF-kappaB transcription factor activity; positive regulation of dendritic cell apoptotic process; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; positive regulation of I-kappaB kinase/NF-kappaB signaling; p38MAPK cascade; negative regulation of natural killer cell mediated cytotoxicity; positive regulation of transforming growth factor beta production; negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of dendritic cell differentiation; negative regulation of tumor necrosis factor production; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; inflammatory response; regulation of p38MAPK cascade; mature conventional dendritic cell differentiation; positive regulation of dendritic cell chemotaxis; positive regulation of activated T cell autonomous cell death;
	Sources:Amigo / QuickGO
Orthologs
	3965
	16859
	ENSG00000168961
	ENSMUSG00000001123
	O00182
	O08573
	NM_002308; NM_009587; NM_001330163
	NM_001159301; NM_010708
	NP_001317092; NP_002299; NP_033665
	NP_001152773; NP_034838
	Wikidata
View/Edit Human	View/Edit Mouse

Galectin-9 was first isolated from mouse embryonic kidney in 1997 as a 36 kDa beta-galactoside lectin protein. Human galectin-9 is encoded by the LGALS9 gene.