LGR6

LGR6
Identifiers
Aliases	LGR6, GPCR, VTS20631, leucine-rich repeat containing G protein-coupled receptor 6, leucine rich repeat containing G protein-coupled receptor 6
External IDs	OMIM: 606653; MGI: 2441805; HomoloGene: 49680; GeneCards: LGR6; OMA:LGR6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,319,781 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	135,033,014 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; left coronary artery; ; granulocyte; ; cardiac muscle tissue of right atrium; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; anterior pituitary;
	Top expressed in
	ascending aorta; ; aortic valve; ; skin of external ear; ; molar; ; secondary oocyte; ; right ventricle; ; median eminence; ; primary oocyte; ; skin of back; ; epidermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity; protein-hormone receptor activity; heparin binding; Roundabout binding;
Cellular component	integral component of membrane; vesicle; plasma membrane; integral component of plasma membrane; trans-Golgi network membrane; membrane; extracellular space;
Biological process	positive regulation of canonical Wnt signaling pathway; positive regulation of Wnt signaling pathway; G protein-coupled receptor signaling pathway; Wnt signaling pathway; signal transduction; positive regulation of cell migration; tissue regeneration; bone regeneration; axon guidance; negative chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	59352
	329252
	ENSG00000133067
	ENSMUSG00000042793
	Q9HBX8
	Q3UVD5
	NM_001017403; NM_001017404; NM_021636
	NM_001033409
	NP_001017403; NP_001017404; NP_067649
	NP_001028581
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene. Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo.

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.