LHX2

LHX2
Identifiers
Aliases	LHX2, LH2, hLhx2, LIM homeobox 2
External IDs	OMIM: 603759; MGI: 96785; HomoloGene: 55848; GeneCards: LHX2; OMA:LHX2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	124,033,301 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	38,259,745 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; hair follicle; ; ganglionic eminence; ; sperm; ; retinal pigment epithelium; ; endothelial cell; ; entorhinal cortex; ; middle temporal gyrus; ; Brodmann area 23; ; Amygdala;
	Top expressed in
	ventricular zone; ; olfactory epithelium; ; ganglionic eminence; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; septum transversum; ; barrel cortex; ; hand; ; hippocampus proper; ; hepatic diverticulum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; sequence-specific DNA binding; chromatin binding; DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus; intracellular anatomical structure;
Biological process	negative regulation of transcription regulatory region DNA binding; mesoderm development; telencephalon development; neural tube closure; retina development in camera-type eye; cerebral cortex development; transcription, DNA-templated; axon guidance; axon extension; hair follicle development; maintenance of epithelial cell apical/basal polarity; neurogenesis; brain development; olfactory bulb development; nervous system development; dorsal/ventral pattern formation; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; neuron differentiation; anatomical structure formation involved in morphogenesis; telencephalon regionalization; transcription by RNA polymerase II; negative regulation of gene expression, epigenetic; negative regulation of neurogenesis; positive regulation of neural precursor cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	9355
	16870
	ENSG00000106689
	ENSMUSG00000000247
	P50458
	Q9Z0S2
	NM_004789
	NM_001290646; NM_010710
	NP_004780
	NP_001277575; NP_034840
	Wikidata
View/Edit Human	View/Edit Mouse

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.