DNA ligase 1

LIG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X9N
Identifiers
Aliases	LIG1, DNA ligase 1, LIGI, hLig1, IMD96
External IDs	OMIM: 126391; MGI: 101789; HomoloGene: 197; GeneCards: LIG1; OMA:LIG1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,170,603 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	13,045,350 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; ventricular zone; ; ganglionic eminence; ; sural nerve; ; mucosa of transverse colon; ; left testis; ; granulocyte; ; gonad; ; right testis; ; testicle;
	Top expressed in
	tail of embryo; ; genital tubercle; ; outer renal medulla; ; fetal liver hematopoietic progenitor cell; ; inner renal medulla; ; primitive streak; ; epiblast; ; somite; ; yolk sac; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; DNA ligase (ATP) activity; metal ion binding; ligase activity; ATP binding; DNA ligase activity;
Cellular component	intracellular membrane-bounded organelle; nucleoplasm; mitochondrion; nucleus; cytoplasm;
Biological process	nucleotide-excision repair, DNA gap filling; DNA recombination; DNA biosynthetic process; anatomical structure morphogenesis; Okazaki fragment processing involved in mitotic DNA replication; cellular response to DNA damage stimulus; cell division; DNA replication; V(D)J recombination; DNA mismatch repair; DNA ligation involved in DNA repair; cell cycle; transcription-coupled nucleotide-excision repair; DNA repair; base-excision repair; DNA ligation; lagging strand elongation;
	Sources:Amigo / QuickGO
Orthologs
	3978
	16881
	ENSG00000105486
	ENSMUSG00000056394
	P18858
	P37913
	NM_000234; NM_001289063; NM_001289064; NM_001320970; NM_001320971
	NM_001083188; NM_001199310; NM_010715
	NP_000225; NP_001275992; NP_001275993; NP_001307899; NP_001307900
	NP_001076657; NP_001186239; NP_034845
	Wikidata
View/Edit Human	View/Edit Mouse

DNA ligase 1 also DNA ligase I, is an enzyme that in humans is encoded by the LIG1 gene. DNA ligase 1 is the only known eukaryotic DNA ligase involved in both DNA replication and repair, making it the most studied of the ligases.