LIMA1

LIMA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D8Y
Identifiers
Aliases	LIMA1, EPLIN, SREBP3, LIM domain and actin binding 1, LDLCQ8
External IDs	OMIM: 608364; MGI: 1920992; HomoloGene: 9484; GeneCards: LIMA1; OMA:LIMA1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	50,283,546 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,773,337 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; tendon of biceps brachii; ; Achilles tendon; ; rectum; ; mucosa of colon; ; mucosa of sigmoid colon; ; subcutaneous adipose tissue; ; jejunal mucosa; ; gastric mucosa;
	Top expressed in
	genital tubercle; ; lacrimal gland; ; transitional epithelium of urinary bladder; ; Rostral migratory stream; ; left colon; ; epithelium of stomach; ; lobe of prostate; ; duodenum; ; pyloric antrum; ; corneal stroma;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin filament binding; actin binding; actin monomer binding; protein binding; metal ion binding; cadherin binding;
Cellular component	cell junction; cleavage furrow; cytoskeleton; brush border; stress fiber; focal adhesion; actin cytoskeleton; cytoplasm;
Biological process	negative regulation of actin filament depolymerization; ruffle organization; actin filament bundle assembly;
	Sources:Amigo / QuickGO
Orthologs
	51474
	65970
	ENSG00000050405
	ENSMUSG00000023022
	Q9UHB6
	Q9ERG0
	NM_001113546; NM_001113547; NM_001243775; NM_016357
	NM_001113545; NM_023063
	NP_001107018; NP_001107019; NP_001230704; NP_057441
	NP_001107017; NP_075550
	Wikidata
View/Edit Human	View/Edit Mouse

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.

EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles (Maul et al., 2003).[supplied by OMIM]