LIN28

LIN28A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQF, 2LI8
Identifiers
Aliases	LIN28A, CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A, lin-28 homolog A, Lin28a, LIN28A (gene), Lin-28 homolog A
External IDs	OMIM: 611043; MGI: 1890546; HomoloGene: 32592; GeneCards: LIN28A; OMA:LIN28A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,429,728 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,746,152 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; sperm; ; gonad; ; buccal mucosa cell; ; testicle; ; left testis; ; right testis; ; embryo; ; Achilles tendon;
	Top expressed in
	primitive streak; ; tail of embryo; ; epiblast; ; otic placode; ; somite; ; otic vesicle; ; yolk sac; ; zygote; ; granulocyte; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; metal ion binding; protein binding; RNA binding; nucleic acid binding; translation initiation factor binding; mRNA binding; G-quadruplex RNA binding; miRNA binding; sequence-specific mRNA binding; polysome binding;
Cellular component	cytoplasm; cytosol; nucleolus; nucleus; endoplasmic reticulum; rough endoplasmic reticulum; polysome; P-body; cytoplasmic stress granule; ribonucleoprotein complex;
Biological process	regulation of gene silencing by miRNA; germ cell development; miRNA catabolic process; regulation of transcription, DNA-templated; RNA 3'-end processing; somatic stem cell population maintenance; negative regulation of glial cell differentiation; positive regulation of translation; stem cell differentiation; positive regulation of cell proliferation involved in kidney development; stem cell population maintenance; pre-miRNA processing; positive regulation of neuron differentiation; miRNA metabolic process; gene silencing; negative regulation of translation; positive regulation of TOR signaling; positive regulation of protein kinase B signaling; cellular response to glucose stimulus; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of cytoplasmic translation;
	Sources:Amigo / QuickGO
Orthologs
	79727
	83557
	ENSG00000131914
	ENSMUSG00000050966
	Q9H9Z2
	Q8K3Y3
	NM_024674
	NM_145833
	NP_078950
	NP_665832
	Wikidata
View/Edit Human	View/Edit Mouse

Lin-28 homolog A is a protein that in humans is encoded by the LIN28 gene.

LIN28 encodes an RNA-binding protein that binds to and enhances the translation of the IGF-2 (insulin-like growth factor 2) mRNA. Lin28 binds to the let-7 pre-microRNA and blocks production of the mature let-7 microRNA in mouse embryonic stem cells. In pluripotent embryonal carcinoma cells, LIN28 is localized in the ribosomes, P-bodies and stress granules.