LINGO1

LINGO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ID5, 4OQT
Identifiers
Aliases	LINGO1, LERN1, LRRN6A, UNQ201, leucine rich repeat and Ig domain containing 1, MRT64
External IDs	OMIM: 609791; MGI: 1915522; HomoloGene: 41891; GeneCards: LINGO1; OMA:LINGO1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	77,820,900 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	56,703,752 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; occipital lobe; ; lateral nuclear group of thalamus; ; Amygdala; ; primary visual cortex;
	Top expressed in
	visual cortex; ; primary motor cortex; ; primary visual cortex; ; piriform cortex; ; superior frontal gyrus; ; cingulate gyrus; ; subiculum; ; anterior amygdaloid area; ; dentate gyrus of hippocampal formation granule cell; ; prefrontal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; epidermal growth factor receptor binding;
Cellular component	membrane; integral component of membrane; plasma membrane; extracellular space; extracellular matrix;
Biological process	negative regulation of axonogenesis; signal transduction; axonogenesis;
	Sources:Amigo / QuickGO
Orthologs
	84894
	235402
	ENSG00000169783
	ENSMUSG00000049556
	Q96FE5
	Q9D1T0
NM_001301186; NM_001301187; NM_001301189; NM_001301191; NM_001301192;
	NM_001301194; NM_001301195; NM_001301197; NM_001301198; NM_001301199; NM_001301200; NM_032808
NM_181074; NM_001311076; NM_001361115; NM_001361116; NM_001361117;
	NM_001361118; NM_001361119; NM_001361120
NP_001288115; NP_001288116; NP_001288118; NP_001288120; NP_001288121;
	NP_001288123; NP_001288124; NP_001288126; NP_001288127; NP_001288128; NP_001288129; NP_116197
NP_001298005; NP_851419; NP_001348044; NP_001348045; NP_001348046;
	NP_001348047; NP_001348048; NP_001348049
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat and Immunoglobulin-like domain-containing protein 1 also known as LINGO-1 is a protein which is encoded by the LINGO1 gene in humans. It belongs to the family of leucine-rich repeat proteins which are known for playing key roles in the biology of the central nervous system. LINGO-1 is a functional component of the Nogo (neurite outgrowth inhibitor) receptor also known as the reticulon 4 receptor.

It has been suggested that LINGO-1 antagonists such as BIIB033 could significantly improve and regulate survival after neural injury caused by the protein.